Centrifuge is a common technique used for separating components of a sample based on their differential densities. Low speed centrifuge, also known as differential centrifuge, is a form of centrifuge that is commonly used to separate proteins, nucleic acids, and other biopolymers. It is different from high speed centrifuge, also known as ultracentrifuge, in that the centrifuge speed is much lower.

One of the main differences between low speed centrifuge and differential centrifuge is the speed at which the centrifuge is performed. In high speed centrifuge, the centrifuge speed can reach speeds of over 100,000 revolutions per minute (RPM), whereas low speed centrifuge typically ranges from 1,000 to 5,000 RPM. This difference in speed can have a significant impact on the separation of components.

Another difference between low speed centrifuge and differential centrifuge is the method used to separate the components. In differential centrifuge, the sample is centrifuged at a low speed to separate the components based on their different densities. The heavier components will sediment to the bottom of the centrifuge tube, while the lighter components will float to the top. This process can be repeated multiple times to achieve greater separation.

In contrast, high speed centrifuge uses extremely high speeds to separate components based on their size, shape, and charge. This technique is often used for separations of large biopolymers such as proteins and nucleic acids. High speed centrifuge can also be used for other applications, such as the separation of cells based on their differential densities.

Low speed centrifuge and differential centrifuge are two different forms of centrifuge that are used for different applications. Low speed centrifuge is commonly used for the separation of proteins, nucleic acids, and other biopolymers, while high speed centrifuge is often used for the separation of large biopolymers. The differences in speed and method used for separation make low speed centrifuge and differential centrifuge two distinct forms of centrifuge.